Thanks so much for posting this. I bought a 1990 ZR1 in Missouri and drove it 13 hours home to Atlanta and read a lot to try and prepare. A few of my thoughts, these were my experiences YMMV.
I wasn't a huge fan of doing hours in the car at highway speeds because of the noise. I tried twice to get earplugs at gas stations, no luck. Between wind noise, engine and exhaust it was just loud.
The seats were the best I've ever used for a road trip. After 13+ hours I had zero fatigue from them.
At 80mph in 6th gear I'm at about 2000 RPM, and so if I hit a hill, I'd need to downshift...such an interesting and useful gear ratio.
She is thirsty on the highway.
One interesting gas station comment: "Beautiful car. That new vette is interesting, but more European looking. This one is for us."