[Hog]

My 57 runs a 3.36:1 rear gear with a 1:1 high gear and its a decent all around gear for a driver. With the blower you dont require the same gearing as if you were naturally aspirated. I personally wouldnt go any higher than 3.42-3.73 if not running an OD, of course depending on tire height.

Of course heads would help, you will probably lose some boost, but boost is merely a measure of restriction, not a measure of power. Only a dyno or the mph reading at a drag strip will measure power.
Boost can drop while power goes up markedly. Kinda like blowing through a straw vs. a garden hose. Sure it requires less pressure to blow through a garden hose, but the amount of air moving is much more.

So far as a cam, you can get decent gains and still remain driveable. Cam and heads will really wake up you combo.